What is SOX2 a marker for?
SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult.
What is SOX2?
Sox2 is one of the key transcription factors that play an essential role in maintaining pluripotency of stem cells. Sox2 interacts with Oct4 to form a binary complex, which then recruits other nuclear factors to activate pluripotent gene expression and repress genes involved in differentiation.
How is SOX2 regulated?
Expression and function of SOX2 is regulated through several post-translational modifications such as ubiquitination, sumoylation, phosphorylation, methylation and acetylation.
What is Nanong?
NANOG is a transcription factor that is involved in the self-renewal of embryonic stem cells (ES) and is a critical factor for the maintenance of the undifferentiated state of pluripotent cells.
How do you inhibit SOX2?
Finally, EGFR inhibitors, Gefitinib and Erlotinib, and Src inhibitor, Dasatinib, are all shown to reduce the levels of SOX2 by blocking the EGFR/SRC/AKT signaling, eventually suppressing the self-renewal properties of cancer stem cells in non-small cell lung cancer (Singh et al., 2012).
What does NANOG stand for?
Acronym. Definition. NANOG. North American Network Operator’S Group.
What is Nanog gene?
NANOG (Nanog Homeobox) is a Protein Coding gene. Diseases associated with NANOG include Teratocarcinoma and Germ Cell And Embryonal Cancer. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Mesodermal commitment pathway.
What chromosome is SOX2 on?
|Gene location (Human)|
|Chr.||Chromosome 3 (human)|
How does NANOG maintain pluripotency?
Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. Nat Cell Biol. 2008 Feb;10(2):194-201.