Are Brenner tumors malignant?
Brenner tumors can be further classified as benign, proliferative (borderline), or malignant by histopathological review. The majority of these tumors are benign or proliferative, with malignant Brenner tumors (MBT) making up <5% of all diagnosed Brenner tumors.
What is Mullerian serous carcinoma?
High-grade serous carcinoma, traditionally presumed to arise within Müllerian inclusion cysts of the ovarian surface, cortex and peritoneum, has recently been linked to the distal fallopian tube.
What is carcinoma of Mullerian origin?
Müllerian epithelial cancers include all epithelial cancers traditionally referred to as ovarian carcinomas in addition to those from organs derived from the Müllerian ducts such as uterus and cervix.
Is Brenner tumor benign?
Brenner tumor of the ovary is a solid, abnormal growth (tumor) on the ovary. Most Brenner tumors are not cancerous (benign). These tumors most often occur in women after menopause. They usually do not cause symptoms unless they are very large.
How common is a Brenner tumor?
Brenner tumor is a very rare tumor (adenofibroma) of the ovary representing 5% of all ovarian tumors 1).
What does Mullerian origin mean?
Adenocarcinoma of Mullerian origin, previously, known as ‘mesothelioma of pelvic origin’, is a rare primary malignancy of the peritoneum . It is frequently found identical to papillary serous adenocarcinoma of the ovary, hence, also referred to as extraovarian peritoneal serous papillary carcinoma.
What is high-grade Mullerian carcinoma?
High-grade Mullerian cancers display predominantly serous histology, but also include some endometrial carcinomas, carcinosarcomas, and undifferentiated cancers.
What causes Brenner tumors?
The cause of Brenner tumors is unknown. They are usually found by accident during surgery for another reason or during a routine doctor’s examination. The diagnosis is made by microscopic examination of a piece of tumor obtained by a surgical biopsy.
What is a Brenner tumor?
Brenner tumor is a rare ovarian tumor that is a part of the surface epithelial group of ovarian neoplasm. It is usually asymptomatic and most of the times it is an incidental pathological finding. Here we present a case of benign Brenner tumor of ovary treated surgically.
Is Mullerian an ovary?
Retrograde menstruation would indicate that endometrioid and clear cell cancers develop from endometrial tissue, the primary Mullerian system, which secondarily involves the ovary .
Can high-grade serous carcinoma be cured?
Is high-grade serous ovarian carcinoma curable? Patients with HGSOC often respond well to treatment, and can experience remission — however, it is common for high-grade serous patients to recur over a period of time, with the majority of recurrences occurring within three years.
What is PAX8 gene?
The PAX8 gene belongs to a family of genes that play critical roles in the formation of tissues and organs during embryonic development. The PAX gene family is also important for maintaining the normal function of certain cells after birth.
What is a Brenner tumor of the ovary?
Brenner tumor of the ovary is a solid, abnormal growth (tumor) on the ovary. Most Brenner tumors are not cancerous (benign). These tumors most often occur in women after menopause.
What is the prognosis of Brenner tumor?
Most Brenner tumors are not cancerous (benign). About 5% of Brenner tumors are cancerous (malignant) or have a small chance of spreading beyond its original location (borderline).    These tumors most often occur in women after menopause. They usually do not cause symptoms unless they are very large.
What causes benign and malignant Brenner tumors?
The cause of benign and malignant Brenner tumors is not known. About 30% of the time, benign Brenner tumors are found along with ovarian cancer.
What does a Brenner tumour look like?
On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumours can vary in size from less than 1 centimetre (0.39 in) to 30 centimetres (12 in). Borderline and malignant Brenner tumours are possible but each are rare.