What is beta-catenin positive tumors?
In summary, high-level nuclear β-catenin staining may be useful as a diagnostic marker for desmoid-type fibromatosis, as only a very limited subset (solitary fibrous tumor, synovial sarcoma, and endometrial stromal sarcoma) of other mesenchymal neoplasms are positive for this marker.
What is the function of beta-catenin?
In the canonical Wnt cascade, β-catenin is the key effector responsible for transduction of the signal to the nucleus and it triggers transcription of Wnt-specific genes responsible for the control of cell fate decisions in many cells and tissues.
What is beta-catenin mutation?
The CTNNB1 gene mutations that cause desmoid tumors usually occur in a region of the gene called exon 3. They change single protein building blocks (amino acids) in the beta-catenin protein. These mutations lead to an abnormally stable beta-catenin protein that is not broken down when it is no longer needed.
What is beta-catenin signaling?
Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal.
What is the beta catenin pathway?
Is beta-catenin an oncogene?
Interaction between HPV and β-catenin The well-known oncogenic model is that E6/E7 binds and inactivates the tumor suppressor proteins p53 and retinoblastoma protein (pRb), respectively, interrupting cell-cycle control and initiating gene transcription [51].
What is beta-catenin cancer?
Beta-catenin is a proto-oncogene. Mutations of this gene are commonly found in a variety of cancers: in primary hepatocellular carcinoma, colorectal cancer, ovarian carcinoma, breast cancer, lung cancer and glioblastoma.
What is the role of β catenin in cancer?
β-Catenin is a crucial transcriptional factor in Wingless–Int (Wnt) signaling, and plays important role in stem cell renewal and organ regeneration [56]. Aberrant expression of β-catenin induces malignant transformation of normal cells, and its abnormal activity has been reported in many cancer types [57].
What is the Wnt/beta catenin pathway?
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular functions such as stem cell regeneration and organogenesis. Several intra-cellular signal transduction pathways are induced by Wnt, notably the Wnt/beta-catenin dependent pathway or canonical pathway and t …
What does beta catenin do in stem cells?
Beta-catenin (β-catenin) is a multifunctional, 90 kD protein that contributes to cell development under normal physiological conditions [55]. β-Catenin is a crucial transcriptional factor in Wingless–Int (Wnt) signaling, and plays important role in stem cell renewal and organ regeneration [56].