How can you tell the difference between intrahepatic and extrahepatic cholestasis?
Ultrasound is the first-line non-invasive imaging procedure in order to differentiate intra- from extrahepatic cholestasis (III/C1). Testing for serum antimitochondrial antibodies (AMA) is mandatory in adults with chronic intrahepatic cholestasis (III/C1).
What does intrahepatic mean?
Medical Definition of intrahepatic : situated or occurring within or originating in the liver intrahepatic cholestasis.
What is intrahepatic and extrahepatic bile duct dilatation?
When the diameter of the left or right hepatic duct exceeds the normal range, and/or with widening of the level-2 and -3 bile ducts, the condition is called intrahepatic bile duct dilatation. An intrahepatic bile duct diameter of 5 mm is called mild, 5-9 mm moderate, and >9 mm severe dilatation.
What is the difference between cholestasis and obstructive jaundice?
Cholestasis is a Greek word that means stopping or slowing of bile flow from the liver to the small intestine due to a block (obstruction) in the biliary duct system that connects the liver and small intestine, causing the bile to remain in the liver. It is therefore a form of obstructive jaundice.
Is the common hepatic duct intrahepatic or extrahepatic?
Extrahepatic bile ducts The extrahepatic ducts include the part of the right and left hepatic ducts that are outside the liver, the common hepatic duct and the common bile duct.
What are extrahepatic organs?
Definition of extrahepatic : situated or originating outside the liver.
What is extrahepatic bile duct?
Extrahepatic bile ducts are small tubes that carry bile outside of the liver. They are made up of the common hepatic duct (hilum region) and the common bile duct (distal region). Bile is made in the liver and flows through the common hepatic duct and the cystic duct to the gallbladder, where it is stored.
What is a extrahepatic bile duct?
What is intra hepatic jaundice?
In hepatocellular (or intrahepatic) jaundice, there is dysfunction of the hepatic cells. The liver loses the ability to conjugate bilirubin, but in cases where it also may become cirrhotic, it compresses the intra-hepatic portions of the biliary tree to cause a degree of obstruction.
What causes intrahepatic jaundice?
The most common intrahepatic causes are viral hepatitis, alcoholic cirrhosis, primary biliary cirrhosis, drug induced jaundice, and alcoholic hepatitis. Posthepatic jaundice is most often due to biliary obstruction by a stone in the common bile duct or by carcinoma of the pancreas.
What is extrahepatic cholestasis?
Extrahepatic cholestasis or obstructive cholestasis is due to excretory block outside of the liver, along with the extrahepatic bile ducts [1][2][3][4] Clinically, cholestasis leads to retention of the constituents of bile in blood. The 2 major constituents of bile are bilirubin and bile acids.
What are the extrahepatic tissue?
What are the intrahepatic ducts?
Intrahepatic bile ducts are a network of small tubes that carry bile inside the liver. The smallest ducts, called ductules, come together to form the right and left hepatic ducts, which lead out of the liver. The two ducts join outside the liver and form the common hepatic duct.
Is common bile duct intrahepatic or extrahepatic?
The extrahepatic bile duct is made up of the perihilar region (the area that is closest to the liver and includes the common hepatic duct) and the distal region (the area that is farthest from the liver and includes the common bile duct). The extrahepatic bile duct is part of the biliary system.
What are the two types of cholestasis?
There are two types of cholestasis: intrahepatic cholestasis and extrahepatic cholestasis. Intrahepatic cholestasis originates within the liver….Cholestasis of pregnancy
- jaundice.
- pale stools.
- dark urine.
- abdominal pain.
- nausea.