What is succinylcholine apnoea?
Suxamethonium Apnoea (Succinlycholine. or Scoline Apnoea) (SA) What is it? Suxamethonium (succinylcholine) is a drug used in anaesthesia to produce relaxation of the muscles (paralysis). It is normally broken down very rapidly in the body by a substance in the blood, an enzyme called plasma cholinesterase.
How is succinylcholine apnea treated?
Every apnea over 15 minutes requires maximal attention of the anesthesiologist. First it is necessary to eliminate other possible causes of apnea. The therapy is based on oxygenation with 100% O2 blood transfusion or transfusion of fresh frozen plasma or preparation of human acetylcholinesterase.
What causes suxamethonium apnoea?
Suxamethonium (succinylcholine) apnoea occurs when a patient has been given the muscle relaxant suxamethonium, but does not have the enzymes to metabolise it. Thus they remain paralysed for an increased length of time and cannot breathe adequately at the end of an anaesthetic.
How common is suxamethonium apnoea?
The incidence of patients susceptible to significant suxamethonium apnoea is 1:2800. Plasma cholinesterase deficiency is inherited in an autosomal recessive inheritance pattern.
What are contraindications of suxamethonium?
Suxamethonium is contraindicated in patients with recent burns or spinal cord trauma causing paraplegia (can be given immediately after the injury, but should be avoided from approximately day 10 to day 100 after the injury), raised potassium levels, severe muscle trauma, or a history of malignant hyperpyrexla.
What causes Suxamethonium sensitivity?
Suxamethonium sensitivity is an autosomal recessive trait due to mutant alleles of CHE1 on chromosome 3; it is most common in Europeans and rare in Asians. Abnormal sensitivity to suxamethonium may also result from other diseases (Box 23.5) or may be a type of hypersensitivity reaction.
What causes suxamethonium Apnoea?
How do you test for suxamethonium Apnoea?
What happens if I have experienced Suxamethonium Apnoea? A blood sample will be taken to measure the total cholinesterase activity and frequently the enzyme phenotype. If the results show that the enzyme level is low or low normal and an abnormal or silent phenotype is present this should be recorded in your notes.
Is succinylcholine and suxamethonium the same?
Suxamethonium chloride, also known as suxamethonium or succinylcholine, or simply sux by medical abbreviation, is a medication used to cause short-term paralysis as part of general anesthesia. This is done to help with tracheal intubation or electroconvulsive therapy.
What is suxamethonium sensitivity?
How do you test for suxamethonium apnoea?
What causes suxamethonium sensitivity?
What is suxamethonium apnoea?
Suxamethonium (succinylcholine) apnoea occurs when a patient has been given the muscle relaxant suxamethonium, but does not have the enzymes to metabolise it. Thus they remain paralysed for an increased length of time and cannot breathe adequately at the end of an anaesthetic.
Can suxamethonium be used to induce spontaneous breathing?
JE Rees, Exeter, UK. action of suxamethonium is terminated by plasma cholinesterase. Spontaneous breathing cannot occur until the action of suxamethonium has ceased. The indications for suxamethonium Suxamethonium is used to intubate patients rapidly.
What is suxamethonium used for?
Suxamethonium is a depolarising muscle relaxant used to rapidly gain optimal intubating conditions. It is normally metabolised within 5 minutes by plasma cholinesterase.
How fast is suxamethonium metabolized?
Suxamethonium is a depolarising muscle relaxant used to rapidly gain optimal intubating conditions. It is normally metabolised within 5 minutes by plasma cholinesterase. Some patients lack this enzyme or have an altered enzyme that does not metabolise the suxamethonium as rapidly.