Can anesthesia cause long QT?
Perioperative management Some anesthetics and some drugs used for premedication may lead to QT-prolongation. The torsadogenic effect is related both to the drug and to the anaesthesiological and surgical manoeuvres.
Does lidocaine affect QT interval?
In conclusion, lidocaine diminishes the prolongation of the corrected QT interval induced by tracheal intubation in patients without cardiovascular disorders.
Does lidocaine cause QT prolongation?
Few authors verified the utility of different drugs to prevent lengthening of QTc interval associated to intubation: Owczuk et al[25] demonstrated that the use of intravenous lidocaine (1.5 mg/kg) before laryngoscopy and intubation prevented prolongation of the QTc interval induced by the maneuver.
Does propofol prolong QTc?
As propofol is historically considered to not prolong the QTc interval, it has been used as an active comparator in studies that evaluate the QTc-prolonging effects of other general anesthetics [Kleinsasser et al. 2000; Michaloudis et al. 1996].
Does propofol prolong QT?
PROPOFOL is a widely used anesthetic drug and does not prolong corrected QT interval as much as other anesthetic agents, including midazolam. 1Propofol is also used for induction and maintenance of general anesthesia, even in patients with either congenital or acquired long QT syndrome.
What medications increase QT interval?
The most potent QT-prolonging medications are antiarrhythmic agents, particularly amiodarone, dofetilide, quinidine, and sotalol, with quinidine possibly having the most torsadogenic potential.
Does midazolam prolong QT?
Neither midazolam nor propofol had any significant effect on QTc interval. Prolongation of QTc was observed in both groups after suxamethonium and this was further prolonged following intubation. Heart rate and arterial pressure were also increased significantly in both groups following intubation.
Can precedex prolong QTc?
Dexmedetomidine appears to have been added to a list of drugs that possibly prolong the QTc based on a single case report where pediatric use of dexmedetomidine unmasked congenital long QT syndrome.
Do opioids prolong QT interval?
Per- haps the most common cardiac side effect of opioids is the prolongation of the QT interval, which can lead to torsades de pointes (TdP), which is a kind of ventricular tachyarrhythmia with the potential of causing sudden death [11–13].
Does ibuprofen prolong QTc?
The duration of the QRS complex wave (QRS duration) in ECG was prolonged. Although the heart rate was depressed by ibuprofen, the corrected QT interval duration (QTc) decreased.
What medications prolong QTc?
Table 2 Some drugs associated with QTc prolongation
- Antibiotics. azithromycin. clarithromycin. erythromycin. roxithromycin. metronidazole. (with alcohol) moxifloxan.
- Antifungals. fluconazole. (in cirrhosis) ketoconazole.
- Antivirals. nelfinavir.
- Antimalarials. chloroquine. mefloquine.
Does propofol increase QT interval?
Does oxycodone increase QTc?
Higher oxycodone dose was also associated with longer QTc (R2 = 0.21; P = 0.02). A 100 mg higher oxycodone dose was associated with a 10 ms1/2 (95% CI 2–19) longer QTc. Neither morphine nor tramadol dose was associated with the QTc.
Does tramadol prolong QTc?
Conclusion: Tramadol produces QTc interval prolongation in good correlation with plasma drug concentrations; renal failure is a risk factor for higher concentration and QT prolongation by tramadol.
Does Toradol prolong QT interval?
Ketorolac has been confirmed to increase QT duration. In one study, a single dose of ketorolac increased the QT duration by > 30 msec. In patients undergoing general anesthesia, a single dose of ketorolac increased QT duration by 58% [10].
What are the guidelines for general anesthetic management of Long QT syndrome?
Actually, there are no definitive guidelines on pre-, peri- and post-operative anesthetic management of congenital long QT syndrome.
What is long QT syndrome and how is it treated?
Keywords: Long QT Syndrome, Torsades de pointes, Anesthesia, QT-prolongation, Anesthetic drugs Core tip:Long QT syndrome is a cardiac conduction disorder characterized by prolongation and increased dispersion of ventricular repolarization, manifested by lengthening of the QT interval on the surface electrocardiography.
Which anesthetics prolong the QTc interval?
Halogenated volatile anesthetics (Halothane, Enfluorane, Isoflurane, Desflurane and Sevoflurane) prolong the QTc interval, even if data is controversial for some of them[39-43]. Isoflurane has been used safely in patients with LQTS[13,44].
What is the QT interval on an electrocardiogram?
The QT interval on the electrocardiogram reflects the time taken for the ventricle to depolarise and repolarise. Long QT syndrome is a conduction disorder characterised by prolongation and dispersion of ventricular repolarisation, making torsade de pointes (‘twisting of the points’) more likely.