What is the difference between technetium and pertechnetate?
Technetium (99mTc) has eight oxidation states 6, from -1 to +7; specifically, the oxidation state of technetium in the pertechnetate anion (99mTcO4-) is +7. The pertechnetate anion is, among the chemical species of technetium, the most stable in aqueous solution 6,7.
What is free Tc99m?
Tc-99m pertechnetate (Na+ 99mTc O4-) is one of the technetium radiopharmaceuticals used in imaging of thyroid, colon, bladder and stomach.
What is technetium-99m pertechnetate scan?
Technetium 99m pertechnetate (99mTcO4−) is a useful radioactive label for thyroid scanning. It is of particular merit when emphasis is placed upon a low dose of thyroid radiation, optimal resolution, and scanning of thyroid glands in which function is decreased or partly blocked.
What is the difference between TC 99 and TC 99m?
Technetium-99 is produced during nuclear reactor operation, and is a byproduct of nuclear weapons explosions. Technetium-99 can be found as a component of nuclear waste. Technetium-99m is a short-lived form of Tc-99 that is used as a medical diagnostic tool.
What is the meaning of pertechnetate?
Medical Definition of pertechnetate : an anion [TcO4]− of technetium used especially in the form of its sodium salt as a radiopharmaceutical in medical diagnostic scanning (as of the thyroid or brain)
How is technetium thyroid scan done?
How does the test work? Tc-99m pertechnetate is injected intravenously into the arm and images of the thyroid are obtained with a scintillation camera approximately 20 minutes later. The radionuclide emits gamma rays (photons) at a predictable rate. The camera is set to detect a predetermined minimum number of photons.
Is Tc-99m safe?
Technetium-99m has a photopeak of gamma-ray emission of 140.5 keV, making it a very minimal risk of toxicity. [3] The short six-hour half-life and rapid excretion from the body limit toxic effects and give enough time to perform its diagnostic imaging, all while limiting radiation exposure to the patient.
How much does technetium-99m cost?
Price quotes are provided for individual Tc-99m pertechnetate doses and for bulk Tc-99m sodium pertechnetate. Most of the prices fall in the range from $0.28 to $0.45 per mCi, but two prices were much higher, about $0.90 per mCi.
Why is technetium-99m used for medical diagnosis?
Technetium can concentrate in several organs depe nding on its chemical form, so there is no primary organ of concern. This is one reason why the short-lived isotope technetium-99m has such wide usage in nuclear medicine as a diagnostic tool.
How much does technetium cost?
Until 1960, technetium was available only in small amounts and the price was as high as $2800/g. It is now commercially available to holders of O.R.N.L. permits at a price of $60/g.
How much does it cost to produce technetium-99m?
In other words, the cost for producing Mo-99 probably range from about $125 to $325 per 6-day curie. The overall cost of producing 12,000 6-day curies of Mo-99 per week to meet 2006 demand at $225 per 6-day curies is about $140 million.
What type of radiation does technetium 99m emit?
gamma-ray emission
Technetium-99m has a photopeak of gamma-ray emission of 140.5 keV, making it a very minimal risk of toxicity. [3] The short six-hour half-life and rapid excretion from the body limit toxic effects and give enough time to perform its diagnostic imaging, all while limiting radiation exposure to the patient.
Why would you need a thyroid scan?
A thyroid scan is a nuclear medicine examination that uses the emissions of gamma rays from radioactive iodine to help determine whether a patient has thyroid problems, including hyperthyroidism, cancer, or other growths.
How long does technetium-99m stay in the body?
Yes, 99mTc decays to 99Tc, which is radioactive. However its half-life is about 211,000 years. Every decay of 99mTc produces an atom of 99Tc, it’s true, BUT, the decay rate of a nuclide is inversely proportional to its half-life.
How is technetium-99m supplied to hospitals?
Technetium-99m is produced in hospitals from Molybdenum-99, which is delivered on a weekly basis in the form of a technetium-molybdenum generator. This is a self-contained device about the size of a coffee maker.
Why is technetium used in medical diagnosis?
Is technetium-99m used in MRI?
Technetium-99m (Tc-99m) sestamibi with or without single photon emission computed tomography (SPECT), ultrasound (US), CT, and magnetic resonance imaging (MRI) all are noninvasive techniques that can detect enlarged or abnormally functioning parathyroid tissue.
Where can you find technetium?
It’s a product of spontaneous uranium fission and although there are no stable isotopes of technetium, you can usually find about a nanogram of technetium in every 5 kilos of the uranium ore, pitchblende.