Can you take phenytoin with tube feeding?
Food and drug interactions If your child receives tube feedings with such a product, give the phenytoin at least 1 hour before or 2 hours after feeding. If your child receives continuous tube feedings, stop the tube feedings for 1 hour before giving the medicine.
Is Dilantin compatible with enteral feedings?
feeding tube in proper position, no restriction as to type of feeding tube (nasogastric, nasoduodenal, gastrostomy, jejunostomy), but both Dilantin and enteral feeding must be given through the same tube.
Do enteral feeds reduce the level of absorption of phenytoin syrup?
Enteral feeds decrease the absorption of Phenytoin.
Can you give Dilantin with milk?
You may give phenytoin with food or milk, but be consistent. Always give phenytoin with food or milk or always give it on an empty stomach. If your child is taking chewable tablets, encourage your child not to swallow them whole. Instead, the chewable tablets may be chewed, crushed, or mixed with food.
Can you open phenytoin ER capsules?
Background: When phenytoin is prescribed for administration via nasogastric tube, immediate-release OR) phenytoin tablets are crushed before use and extended-release (ER) phenytoin capsules are opened and only the granules are used.
What are the drug administration guidelines for enteral drugs?
Safe administration of medicines via enteral feeding tubes
- never mix drugs. use disposable tablet crushers (not pestle and mortar) to crush one medicine at a time and wash between crushes.
- flush with an appropriate volume of water before administering another drug.
- repeat until all drugs have been administered.
Can phenytoin tablets be crushed?
How is phenytoin administered?
Phenytoin comes as an extended-release (long-acting) capsule, a chewable tablet, and a suspension (liquid) to take by mouth. The chewable tablet and suspension are usually taken two or three times a day. The extended-release capsules are usually taken one to four times a day.
Should phenytoin be taken with food?
It is suggested that phenytoin should always be taken in a defined relation to meals.
Does phenytoin interact with milk?
Adverse gastrointestinal symptoms from milk may reduce the bioavailability of phenytoin.
What medications should not be crushed for administration?
Drugs that should not be crushed are those that are:
- Designed to be controlled release.
- Coated for protection or taste.
- Liquid-filled gel capsules.
- Hazardous or irritants.
- Intended for a small therapeutic window.
What is a guideline when administering phenytoin Dilantin intravenously?
The rate of administration for IV Dilantin should be no greater than 50 mg per minute in adults and 1-3 mg/kg/min (or 50 mg per minute, whichever is slower) in pediatric patients. Serum concentrations should be monitored and care should be taken when switching a patient from the sodium salt to the free acid form.
Does Dilantin need to be taken on an empty stomach?
Take this medication by mouth usually once a day or in divided doses as directed by your doctor. You may take it with food if stomach upset occurs. Take this medication with a full glass (8 ounces or 240 milliliters) of water unless your doctor directs you otherwise. Swallow the capsules whole.
What is the interaction between phenytoin and Enteral tube feeding?
phenytoin, enteral tube feeding, drug-nutrition interaction. Though the interaction between enteral tube feeding and phenytoin was first described 30 years ago, the mechanism of the interaction is still poorly understood. 1 One theory is that the drug can adhere to the plastic tubing when phenytoin is given via tube.
Should phenytoin levels be measured in patients with enteral nutrition?
It may also be useful to measure free phenytoin levels if possible, as many patients requiring enteral nutrition have some degree of malnutrition and altered protein binding with phenytoin due to hypoalbuminemia.
What are the treatment options for phenytoin toxicity?
The first and most important intervention is to stagger the administration of phenytoin to separate it as much as possible from the tube feedings.
When to increase the dose of phenytoin?
If the patient has been stabilized on a therapeutic oral or intravenous dose, it is common clinical practice to start with a 50% empiric increase in dose once enteral nutrition is initiated. It is also important to remember to reduce the dose if tube feeds are held, stopped or if the phenytoin administration route is changed to oral or IV.