What is the phenotype of NK cells?
Human natural killer (NK) cells are phenotypically defined as CD3−CD56+ lymphocytes. They constitute a heterogeneous blood cell population and subsets can be defined depending on their level of expression of CD16 and CD56.
What is CD16 CD56 natural killer cells?
Natural killer (NK) cells are phenotypically defined as lymphocytes expressing the antigens CD56 and mostly CD16 (Fc gamma RIII), but lacking CD3. A small CD3- CD16- CD56+ NK cell subset has been described in normal individuals representing less than 2% of peripheral blood lymphocytes.
What is the main function of NK cells?
Natural killer (NK) cells are effector lymphocytes of the innate immune system that control several types of tumors and microbial infections by limiting their spread and subsequent tissue damage.
How do you identify NK cells?
NK cells in human are identified as CD3−CD56+ cells. They represent 2–7% of lymphocytes in mouse peripheral blood (PB) and 5–15% of human peripheral blood mononuclear cells (PBMCs). NK cells are present in the skin, gut, liver, lung, uterus, kidney, joints, and breast under physiological conditions.
Are NK cells CD11b positive?
CD11b+ SP NK cells had the highest CD16 expression among all three types of human NK cells (Fig. 6b,c), suggesting that they have the strongest cytotoxic capacity. CD11b+ single-positive natural killer (SP NK) cells have the best ability for killing.
What does CD56 negative mean?
Related Articles for “” Furthermore, CD56 negativity may be associated with a poor prognosis, extramedullary involvement, plasmablastic morphology, a plasma-cell leukemic state, and nonhyperdiploidy chromosomal abnormality.
Where are NK cells found?
NK cells develop in bone marrow as well as in some extramedullar sites, such as lymph nodes, thymus, liver, and uterus. NK cell development is controlled by both extracellular and intracellular factors.
What is the marker for NK cells?
In C57BL/6 mice, NK cells are identified by the presence of NK1. 1 (NKR-P1C) and NCR1 (NKp46/CD335), as well as CD49b (DX5, Integrin VLA-2α), are common NK cell markers in other mouse backgrounds (19, 20). NK cells are most similar to a group of lymphocytes known as innate lymphoid cells (ILCs) (21).
What is CD56 positive plasma cells?
CD56 (a neural cell adhesion molecule, NCAM) is a mem- brane glycoprotein belonging to the immunoglobulin super- family1). Normal plasma cells do not express CD56, but it is fre- quently expressed by malignant plasma cells in patients with multiple myeloma (MM) or AL amyloidosis (ALA)2,3).